Southern Illinois University Edwardsville (commonly abbreviated as SIUE), is a public university in Edwardsville, Illinois. SIUE was established in 1957 as an extension of Southern Illinois University Carbondale. It is the younger of the two major institutions of Southern Illinois University system, and, as of 2018, has the larger enrollment. The University offers graduate programs through its Graduate School.

The majority of SIUE's students are from Illinois, with out-of-state and international students accounting for 18% of enrollment. As of 2018, for nearly all of its academic programs, SIUE does not charge out-of-state tuition and fee rates, such that the standard rates are the same for all U.S. residents. The university offers numerous extracurricular activities to its students, including athletics, honor societies, student clubs and organizations, as well as fraternities and sororities. The university has more than 101,000 alumni.